Protein hydrolysates from macro-and microalgae have been reported by various authors as possible therapeutic agents due to their antimicrobial and antiviral 3, 4, anticancer 5, antioxidant 6– 9, and immunoregulatory functions 10. Hence, sponges, algae, and bryozoans, among many other marine organisms, are important sources of bioactive compounds with interesting properties like antioxidant, antimicrobial, anticancer, antihypertensive, and anti-inflammatory activities 1, 2. Due to the complex habitats in which they live, marine organisms can produce a wide variety of secondary metabolites that cannot be found elsewhere. The ocean covers more than 70% of the earth's surface, and therefore marine biodiversity is an essential part of the global system since a large part of human food consumption is derived from marine resources, and global food demands are continually rising. Pearson's correlation test and Principal Component Analysis revealed significant correlations between (1) total peptide and hydrophobic amino acid content in EPHs and their antioxidant activities, and (2) concentrations of taurine, homotaurine, and amino acid gamma aminobutyric acid in EPHs and their SIRT1 modulation activity. Moreover, 19 samples exhibited SIRT1 activation, while EPHs from the 16 samples were SIRT1 inhibitors. High antioxidant activities were observed in EPHs from red and green seaweed species. The objective of this work was to assess and compare the antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates (EPHs) from a wide number of algae species (24 commercial samples and 12 samples harvested off the Atlantic coast of northern Spain). SIRT1 activating and inhibiting compounds, such as polyphenols and bioactive peptides, have been proposed to be involved in the development of many human diseases. Sirtuins, a family of NAD + dependent deacylase enzymes, could be pivotal targets of novel preventive and therapeutic strategies to achieve such aims. Prevention and control of diseases and delaying the signs of ageing are nowadays one of the major goals of biomedicine.
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